Interaction of manganese with striatal dopamine turnover in human alpha-synuclein transgenic mice
نویسندگان
چکیده
Background It is thought that the interaction of genetic and environmental factors is an important risk factor for Parkinson’s disease (PD). a-Synuclein (a-syn) is a protein of special interest in PD because mutations in a-syn (A53T or A30P or E46K) lead to PD. Manganese (Mn) is a heavy metal known to cause parkinsonian symptoms. Therefore, we investigate the effect of manganese (Mn) on human a-syn-expressing mice.
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عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2010